Description
The difference
Unlock Your Potential
MOTS-c is a mitochondrial-derived peptide (MDP) composed of 16 amino acids, which plays a critical role in cellular metabolic regulation. Synthesized within mitochondria, MOTS-c functions by modulating the cellular energy balance through pathways involved in glucose metabolism, insulin sensitivity, and cellular stress response. MOTS-c exerts its effects by translocating to the nucleus, where it influences the expression of genes related to mitochondrial biogenesis and metabolic regulation, particularly under conditions of metabolic stress. Research has shown this peptide to improve exercise capacity, reduce obesity, insulin resistance and other disease processes such as osteoporosis and the mitigation of metabolic disorders and age-associated diseases.
The Mitochondrial-Derived Peptide MOTS-c promotes metabolic homeostasis and longevity, improves exercise capacity, reduces obesity, insulin resistance and other disease processes such as osteoporosis.
MOTS-c Overview
Muscle Metabolism
Research in mice indicates the MOTS-c can reverse age-dependent insulin resistance in muscles, thereby improving muscle uptake of glucose. It does this by improving skeletal muscle response to AMPK activation, which in turn increases the expression of glucose transporters. It is important to note that this activation is independent of the insulin pathway and thus offers an alternative means of boosting glucose uptake by muscles when insulin is ineffective or in insufficient quantity. The net result is improved muscle function, enhanced muscle growth, and decreased functional insulin resistance.
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